Prepulse inhibition is a neurological phenomenon in which a weaker pre-stimulus—a prepulse—inhibits the reaction of an organism to a subsequent startling stimulus. The reduction of the startle reflex reflects the ability of the nervous system to adapt to a strong sensory stimulus when a preceding weaker signal provides it advance warning. The phenomenon has been detected in numerous species, including humans. Disruption of prepulse inhibition has been reported in patients with what diseases?
Back in the day
Designed by Frank Lloyd Wright and opened six months after his death, the Guggenheim Museum represents a radical departure from traditional museum design, spiraling upward and outward in a smooth coil of massive, unadorned white concrete. The exhibition space, which consists of a six-story spiral ramp lighted by a glass dome supported by stainless steel, has even been criticized for upstaging the artwork displayed. What artists signed a letter protesting the display of their work in the space?
Born on a day like today
Solti was a Hungarian-born British conductor. Not long after making his piano debut at age 12, he decided he wanted to conduct. He returned to piano during WWII and won the 1942 Geneva International Competition. After the war, he began conducting again and led orchestras all over Europe and the US. As director of the Royal Opera House, he made the first full recording of Richard Wagner's Ring cycle, one of history's most celebrated recordings. How did he earn the nickname "the screaming skull"?